Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4844537 | 0.91 | PGR (0.38) | RAB9APGRNPC1SMN1; SMN2HPGD | |
| SCHEMBL4842742 | 0.87 | RAB9A (0.38) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL4841185 | 0.86 | TGM2 (0.37) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL4843983 | 0.85 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL4835742 | 0.84 | TP53 (0.43) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL14181769 | 0.83 | MAPT (0.39) | RAB9ASMN1; SMN2TP53MAPTHSP90AA1 | |
| SCHEMBL4843746 | 0.80 | RAB9A (0.38) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL14181858 | 0.79 | RAB9A (0.39) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL4841022 | 0.79 | CDYL2 (0.38) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL4835482 | 0.77 | MAPT (0.43) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378428-B2 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-27 | — | — | US | disclosed |