Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182786 | 0.93 | ITK (0.47) | ITKMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL14182809 | 0.89 | CNR1 (0.36) | ITKMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL14182805 | 0.88 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDTP53NPC1 | |
| SCHEMBL14213889 | 0.83 | ITK (0.40) | ITKMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL14182800 | 0.82 | RAB9A (0.38) | KDM4EALDH1A1HPGDTP53NPC1 | |
| SCHEMBL14183014 | 0.81 | ITK (0.48) | ITKMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL14183008 | 0.81 | ITK (0.48) | ITKMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL14182999 | 0.81 | ITK (0.48) | ITKMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL14182801 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDTP53NPC1 | |
| SCHEMBL14182789 | 0.81 | ITK (0.51) | ITKMAOAMAOBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |