Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 12/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182810 | 0.89 | RAB9A (0.40) | GRM4KDREGFRERBB2MET | |
| SCHEMBL14183012 | 0.88 | GRM4 (0.44) | GRM4KDREGFRERBB2MET | |
| SCHEMBL14182795 | 0.88 | GRM4 (0.48) | GRM4KDREGFRERBB2MET | |
| SCHEMBL14182798 | 0.88 | GRM4 (0.48) | GRM4KDREGFRERBB2MET | |
| SCHEMBL14183005 | 0.88 | GRM4 (0.44) | GRM4KDREGFRERBB2MET | |
| SCHEMBL14182811 | 0.85 | CNR1 (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14182794 | 0.84 | KDR (0.46) | GRM4KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14182791 | 0.83 | ITK (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14182698 | 0.81 | GRM4 (0.44) | GRM4KDREGFRERBB2MET | |
| SCHEMBL14182638 | 0.81 | GRM4 (0.44) | GRM4KDREGFRERBB2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |