Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182811 | 0.94 | CNR1 (0.41) | ITKMAOAMAOBCNR1CNR2 | |
| SCHEMBL14182791 | 0.93 | ITK (0.48) | ITKMAOAMAOBSLC2A1PTPN1 | |
| SCHEMBL14182788 | 0.90 | ITK (0.51) | ITKMAOAMAOBSLC2A1PTPN1 | |
| SCHEMBL14182789 | 0.90 | ITK (0.51) | ITKMAOAMAOBSLC2A1PTPN1 | |
| SCHEMBL14182996 | 0.89 | ITK (0.52) | ITKMAOAMAOBSLC2A1PTPN1 | |
| SCHEMBL14183009 | 0.89 | ITK (0.52) | ITKMAOAMAOBSLC2A1PTPN1 | |
| SCHEMBL14183010 | 0.87 | ITK (0.45) | ITKMAOAMAOBCNR1CNR2 | |
| SCHEMBL14182810 | 0.83 | RAB9A (0.40) | ITKCNR1CNR2SLC2A1KDM4E | |
| SCHEMBL14182707 | 0.81 | MAOA (0.61) | ITKMAOAMAOBSLC2A1PTPN1 | |
| SCHEMBL14182683 | 0.81 | MAOA (0.61) | ITKMAOAMAOBSLC2A1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |