Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532247 | 0.83 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL4533896 | 0.81 | TRPV1 (0.43) | TRPV1BRD4 | |
| SCHEMBL4517072 | 0.81 | TRPV1 (0.43) | TRPV1POLB | |
| SCHEMBL4522753 | 0.76 | TRPV1 (0.41) | TRPV1NPSR1CHEK2POLBMAPT | |
| SCHEMBL13177116 | 0.68 | F2 (0.44) | TRPV1PDE10ACHEK2BRD4 | |
| SCHEMBL16927509 | 0.67 | ALDH1A1 (0.41) | TRPV1PDE10AMEN1POLBKMT2A | |
| SCHEMBL20494892 | 0.66 | DGAT1 (0.42) | NPSR1TNKSDGAT1KCNH2POLB | |
| SCHEMBL4525227 | 0.66 | MAOB (0.44) | TRPV1PDE10AMEN1POLBMAPT | |
| SCHEMBL4536251 | 0.66 | NPC1 (0.50) | TRPV1PDE10AMEN1POLBKMT2A | |
| SCHEMBL4512876 | 0.66 | RAB9A (0.45) | TRPV1PDE10AMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076752-A1 | BENZIMIDAZOLE TRPV1 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-26 | — | — | WO | disclosed |