Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | TFDP2 | Q14188 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536251 | 0.82 | NPC1 (0.50) | PDE10ATRPV1 | |
| SCHEMBL16927522 | 0.72 | TRPV1 (0.49) | PRKAG1PRKAA2PRKAB1CHEK2TRPV1 | |
| SCHEMBL5680411 | 0.70 | TRPA1 (0.52) | F2PLGPRSS1TRPA1 | |
| SCHEMBL321771 | 0.70 | KIF11 (0.56) | — | |
| SCHEMBL4530589 | 0.69 | NPC1 (0.45) | TRPA1PDE10ATRPV1 | |
| SCHEMBL4512876 | 0.69 | RAB9A (0.45) | PDE10ATRPV1 | |
| SCHEMBL4515791 | 0.69 | RAB9A (0.45) | PDE10ATRPV1 | |
| SCHEMBL4554335 | 0.68 | NPC1 (0.44) | PDE10ATRPV1 | |
| SCHEMBL4514053 | 0.68 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL14191928 | 0.68 | TRPV1 (0.37) | PDE10ACHEK2TRPV1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021330-B1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-22 | — | — | EP | disclosed |