SCHEMBL14192598

SCHEMBL14192598

C=CC(=O)c1ccc(C#Cc2ccc(-c3ccc4c(c3)Cc3cc(-c5ccc(C#Cc6ccc(C(=O)C=C)cc6)cc5)ccc3-4)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 6/20 0.41
MAPT P10636 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
ALDH5A1 P51649 1/20 0.40
ABAT P80404 1/20 0.40
AKT1 P31749 1/20 0.38
SRD5A2 P31213 1/20 0.37
HSD17B1 P14061 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
EGFR P00533 1/20 0.36
TP53 P04637 1/20 0.36
CYP3A4 P08684 1/20 0.36
PKM P14618 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
ALOX12 P18054 1/20 0.36
JAK1 P23458 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14192600 0.94 MAPT (0.41) TDP2MAPTNPC1RAB9AALDH5A1
SCHEMBL14192577 0.90 MAPT (0.44) MAPTNPC1RAB9AALDH5A1ABAT
SCHEMBL14218951 0.79 NPC1 (0.38) MAPTNPC1RAB9AALDH5A1ABAT
SCHEMBL8836273 0.78 MAPT (0.58) MAPTNPC1RAB9AALDH5A1ABAT
SCHEMBL14192454 0.78 ALDH5A1 (0.61) MAPTRAB9AALDH5A1ABATAKT1
SCHEMBL14192590 0.78 MEN1 (0.51) MAPTALDH5A1ABATAKT1KDM4E
SCHEMBL14192491 0.77 ACACB (0.45) MAPTNPC1KDM4EMEN1ALDH1A1
SCHEMBL14219185 0.74 CYP1A2 (0.39) ALDH5A1ABATAKT1
SCHEMBL14192579 0.73 ALDH5A1 (0.41) MAPTALDH5A1ABATAKT1KDM4E
Acrylic Acid SCHEMBL31711443 0.73 TDP2 (0.51) TDP2SRD5A2EGFRCYP3A4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7357964-B2 Liquid-crystalline vinyl ketone derivatives and their polymers CHISSO CORPORATION (JP) 2008-04-15 US disclosed
US-7357964-B2 Liquid-crystalline vinyl ketone derivatives and their polymers CHISSO CORPORATION (JP) 2008-04-15 US disclosed