Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902498 | 0.91 | ALDH1A1 (0.58) | HTTALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4906326 | 0.88 | MTNR1A (0.54) | HTTALDH1A1SMN1; SMN2SFRP1PDE4B | |
| SCHEMBL11170701 | 0.76 | ALDH1A1 (0.51) | HTTALDH1A1SMN1; SMN2PDE4BPDE4C | |
| SCHEMBL4906055 | 0.74 | HTT (0.59) | HTTALDH1A1SMN1; SMN2SFRP1MAPT | |
| SCHEMBL29123955 | 0.74 | MAPT (0.72) | HTTALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL11186378 | 0.72 | MAPT (0.67) | HTTALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4902642 | 0.72 | LMNA (0.60) | ALDH1A1SMN1; SMN2SFRP1MAPTLMNA | |
| SCHEMBL11171979 | 0.72 | GAA (0.58) | ALDH1A1MAPTKDM4ELMNAMEN1 | |
| SCHEMBL5960050 | 0.72 | ALDH1A1 (0.77) | HTTALDH1A1SMN1; SMN2PDE4BPDE4C | |
| SCHEMBL5960056 | 0.72 | HTT (1.00) | HTTALDH1A1SMN1; SMN2SFRP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | HTT 696/4885ALDH1A1 2956/4885SMN1; SMN2 3404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.