Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198656 | 0.88 | HTT (0.54) | HTTALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4906055 | 0.87 | HTT (0.59) | MTNR1AMTNR1BHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4902498 | 0.82 | ALDH1A1 (0.58) | HTTALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4904495 | 0.81 | HTT (0.59) | MTNR1AMTNR1BHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7825765 | 0.77 | CTSV (0.58) | SMN1; SMN2CTSVCTSLHDAC1 | |
| SCHEMBL4906333 | 0.76 | NPC1 (0.48) | ALDH1A1SMN1; SMN2CTSVCTSLAPP | |
| SCHEMBL11170701 | 0.75 | ALDH1A1 (0.51) | HTTALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL29123955 | 0.75 | MAPT (0.72) | HTTALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL30028243 | 0.74 | MTNR1A (0.86) | MTNR1AMTNR1BALDH1A1KDM4EBCHE | |
| SCHEMBL4618198 | 0.74 | SFRP1 (0.72) | HTTALDH1A1SMN1; SMN2SFRP1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | MTNR1A 185/4885MTNR1B 247/4885HTT 711/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | MTNR1A 179/4885MTNR1B 255/4885HTT 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.