Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 15/20 | 0.71 |
| ▸ | NPC1 | O15118 | 13/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.61 |
| ▸ | RELA | Q04206 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | STAT1 | P42224 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19267603 | 0.81 | RAB9A (0.72) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19627035 | 0.80 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL22753353 | 0.78 | ROCK2 (0.68) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL19626490 | 0.78 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL27885076 | 0.76 | NFKB1 (1.00) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL16404739 | 0.76 | RAB9A (0.85) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL16217072 | 0.76 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23560422 | 0.75 | MTNR1B (0.57) | RAB9ANPC1ALDH1A1MAPTMEN1 | |
| SCHEMBL11186170 | 0.75 | ROCK2 (0.64) | RAB9AKMT2AGAAHTT | |
| SCHEMBL1553464 | 0.74 | ROCK2 (0.55) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081808-A1 | AZAINDOLE INHIBITORS OF AURORA KINASES | SMITHKLINE BEECHAM CORPORATION | 2008-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081808-A1 | AZAINDOLE INHIBITORS OF AURORA KINASES | AURKA, AURKC, AURKB | RAB9A 2554/4885NPC1 1498/4885SMN1; SMN2 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.