⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201304 | 0.86 | CA1 (0.36) | — | |
| SCHEMBL14200428 | 0.85 | — | — | |
| SCHEMBL14200430 | 0.85 | CNR2 (0.33) | — | |
| SCHEMBL14200435 | 0.84 | — | — | |
| SCHEMBL14200419 | 0.83 | ALDH1A1 (0.30) | — | |
| SCHEMBL14200434 | 0.83 | CA2 (0.33) | — | |
| SCHEMBL14200390 | 0.83 | TP53 (0.32) | — | |
| SCHEMBL14200413 | 0.82 | PIK3CD (0.36) | — | |
| SCHEMBL14201184 | 0.82 | CNR2 (0.32) | — | |
| SCHEMBL14200427 | 0.82 | CA2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |