Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | CES1 | P23141 | 4/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200434 | 0.98 | CA2 (0.33) | CA2CNR2FAAHCES1MMP3 | |
| SCHEMBL14200430 | 0.94 | CNR2 (0.33) | CNR2MMP3 | |
| SCHEMBL14228930 | 0.85 | CNR2 (0.41) | CA2CNR2FAAHCES1MMP3 | |
| SCHEMBL14200358 | 0.84 | CNR2 (0.40) | CA2CNR2FAAHCES1CES2 | |
| SCHEMBL14200355 | 0.84 | CNR2 (0.40) | CA2CNR2FAAHCES1CES2 | |
| SCHEMBL14201273 | 0.84 | FAAH (0.38) | CA2CNR2FAAHCES1CES2 | |
| SCHEMBL14200363 | 0.84 | FAAH (0.38) | CA2CNR2FAAHCES1CES2 | |
| SCHEMBL14228928 | 0.84 | CNR2 (0.39) | CA2CNR2FAAHCES1MMP3 | |
| SCHEMBL14200419 | 0.83 | ALDH1A1 (0.30) | — | |
| SCHEMBL14200424 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |