Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200467 | 0.92 | MAPK1 (0.37) | MAPK1L3MBTL1EPHX1CETPTSHR | |
| SCHEMBL14200451 | 0.91 | PRKCA (0.36) | EPHX1CETPALDH1A1CNR2PPARG | |
| SCHEMBL14200452 | 0.87 | SIGMAR1 (0.37) | MAPK1L3MBTL1CETPTSHRTDP1 | |
| SCHEMBL14200442 | 0.87 | MAPK1 (0.37) | MAPK1L3MBTL1EPHX1TSHRTDP1 | |
| SCHEMBL14200503 | 0.86 | ALDH1A1 (0.46) | TDP1ALDH1A1SMN1; SMN2PPARGPPARA | |
| SCHEMBL14229687 | 0.86 | TP53 (0.40) | MAPK1L3MBTL1EPHX1TSHRTDP1 | |
| SCHEMBL14200995 | 0.85 | RIPK1 (0.39) | L3MBTL1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14200447 | 0.85 | MAPK1 (0.36) | MAPK1L3MBTL1EPHX1CETPTSHR | |
| SCHEMBL14200444 | 0.85 | ALDH1A1 (0.42) | EPHX1ALDH1A1NPC1HPGD | |
| SCHEMBL14200476 | 0.84 | LTB4R2 (0.44) | SMN1; SMN2NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |