Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200471 | 0.93 | ALDH1A1 (0.41) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14200469 | 0.90 | ALDH1A1 (0.41) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14200486 | 0.90 | ALDH1A1 (0.44) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14200501 | 0.86 | RIPK1 (0.38) | — | |
| SCHEMBL14200835 | 0.86 | RIPK1 (0.33) | — | |
| SCHEMBL14229693 | 0.86 | ALDH1A1 (0.45) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14200487 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14201017 | 0.85 | CYP1A2 (0.34) | KDM4E | |
| SCHEMBL14200485 | 0.85 | ALDH1A1 (0.39) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14200448 | 0.82 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |