Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200887 | 0.93 | POLB (0.33) | — | |
| SCHEMBL14200779 | 0.90 | PSEN1 (0.32) | RIPK1 | |
| SCHEMBL14543583 | 0.90 | RIPK1 (0.34) | RIPK1 | |
| SCHEMBL14200734 | 0.90 | RIPK1 (0.34) | RIPK1KCNQ3KCNQ2 | |
| SCHEMBL14200501 | 0.87 | RIPK1 (0.38) | RIPK1 | |
| SCHEMBL14200480 | 0.86 | ALDH1A1 (0.43) | — | |
| SCHEMBL14201017 | 0.86 | CYP1A2 (0.34) | RIPK1 | |
| SCHEMBL14543580 | 0.85 | TP53 (0.35) | — | |
| SCHEMBL14201104 | 0.85 | CHRNA1 (0.36) | — | |
| SCHEMBL14229303 | 0.85 | RIPK1 (0.43) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |