Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200497 | 0.93 | RIPK1 (0.36) | RIPK1HDAC8 | |
| SCHEMBL14200491 | 0.90 | RIPK1 (0.36) | RIPK1HDAC8TAS1R3TAS1R1 | |
| SCHEMBL14200498 | 0.90 | RIPK1 (0.39) | RIPK1HDAC8POLQ | |
| SCHEMBL14200835 | 0.87 | RIPK1 (0.33) | RIPK1 | |
| SCHEMBL14200480 | 0.86 | ALDH1A1 (0.43) | — | |
| SCHEMBL14201017 | 0.86 | CYP1A2 (0.34) | RIPK1HDAC8TAS1R3TAS1R1 | |
| SCHEMBL14229355 | 0.85 | TP53 (0.35) | RIPK1 | |
| SCHEMBL14200500 | 0.85 | RIPK1 (0.38) | RIPK1HDAC8POLQ | |
| SCHEMBL14543454 | 0.85 | RIPK1 (0.49) | RIPK1 | |
| SCHEMBL14200495 | 0.84 | RIPK1 (0.34) | RIPK1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |