Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GPX4 | P36969 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229241 | 0.88 | TP53 (0.49) | CETPNPC1RAB9APAX8ALDH1A1 | |
| SCHEMBL14200337 | 0.87 | MTNR1A (0.53) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL14200462 | 0.82 | CETP (0.50) | CETPGRM2PTGDR2PPARGPPARA | |
| SCHEMBL14200328 | 0.82 | LTB4R2 (0.49) | CETPNPC1RAB9APAX8ALDH1A1 | |
| SCHEMBL14200332 | 0.80 | ALDH1A1 (0.64) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL14200474 | 0.79 | CETP (0.46) | CETPGRM2PTGDR2PPARGPPARA | |
| SCHEMBL14200338 | 0.79 | ALDH1A1 (0.50) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL14200819 | 0.79 | TP53 (0.47) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL14200463 | 0.79 | CETP (0.48) | CETPGRM2HDAC8 | |
| SCHEMBL14200475 | 0.79 | CETP (0.46) | CETPGRM2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |