Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GPX4 | P36969 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200332 | 0.85 | ALDH1A1 (0.64) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14229341 | 0.85 | LTB4R2 (0.58) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14200338 | 0.84 | ALDH1A1 (0.50) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14200819 | 0.84 | TP53 (0.47) | NPC1RAB9APAX8TP53ALDH1A1 | |
| SCHEMBL14200330 | 0.83 | MLYCD (0.44) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14200236 | 0.83 | NPC1 (0.60) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14200572 | 0.83 | TP53 (0.46) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14200574 | 0.83 | NPC1 (0.48) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14200337 | 0.82 | MTNR1A (0.53) | LTB4R2NPC1RAB9APAX8TP53 | |
| SCHEMBL14200516 | 0.82 | CETP (0.45) | LTB4R2NPC1RAB9APAX8TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |