Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.48 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200861 | 0.93 | RIPK1 (0.46) | RIPK1BMP1MDM2HTTKDM4E | |
| SCHEMBL14200851 | 0.90 | RIPK1 (0.50) | RIPK1BMP1MDM2HTTKDM4E | |
| SCHEMBL14200878 | 0.89 | RIPK1 (0.47) | RIPK1BMP1MDM2HTTKDM4E | |
| SCHEMBL14229299 | 0.86 | RIPK1 (0.45) | RIPK1BMP1HTTKDM4EALDH1A1 | |
| SCHEMBL14200846 | 0.85 | TAS1R3 (0.36) | RIPK1KDM4EALDH1A1RAB9AHPGD | |
| SCHEMBL14200792 | 0.84 | RIPK1 (0.45) | RIPK1BMP1MDM2HTTKDM4E | |
| SCHEMBL14200909 | 0.84 | RIPK1 (0.49) | RIPK1BMP1MDM2HTTKDM4E | |
| SCHEMBL14200859 | 0.82 | PSEN1 (0.39) | — | |
| SCHEMBL14200831 | 0.81 | LDHA (0.43) | HTTALDH1A1RAB9AHPGD | |
| SCHEMBL14200932 | 0.80 | HPGD (0.40) | HTTALDH1A1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |