Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200894 | 0.92 | NPC1 (0.36) | TAS1R3TAS1R1LMNAHDAC1HDAC6 | |
| SCHEMBL14200896 | 0.89 | LMNA (0.36) | TAS1R3TAS1R1LMNAHDAC1HDAC6 | |
| SCHEMBL14200765 | 0.88 | TAS1R3 (0.36) | TAS1R3TAS1R1LMNAHDAC1HDAC6 | |
| SCHEMBL14229924 | 0.85 | TAS1R3 (0.39) | TAS1R3TAS1R1LMNAALDH1A1POLB | |
| SCHEMBL14200932 | 0.85 | HPGD (0.40) | TAS1R3TAS1R1LMNANPC1HPGD | |
| SCHEMBL14200859 | 0.85 | PSEN1 (0.39) | SMN1; SMN2 | |
| SCHEMBL14200864 | 0.85 | RIPK1 (0.48) | HPGDRAB9AALDH1A1RIPK1KDM4E | |
| SCHEMBL14200776 | 0.84 | NPC1 (0.35) | TAS1R3TAS1R1LMNAHDAC1HDAC6 | |
| SCHEMBL14200827 | 0.83 | TRPM8 (0.37) | TAS1R3TAS1R1LMNAHDAC1HDAC6 | |
| SCHEMBL14200831 | 0.83 | LDHA (0.43) | LMNANPC1HPGDRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |