Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FDFT1 | P37268 | 5/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201040 | 0.92 | ALDH1A1 (0.36) | ALDH1A1FDFT1MLYCDTP53 | |
| SCHEMBL14229418 | 0.85 | TP53 (0.42) | LMNAALDH1A1NPSR1FDFT1MLYCD | |
| SCHEMBL14228991 | 0.82 | KDM4E (0.36) | LMNAALDH1A1NPSR1MLYCDPOLB | |
| SCHEMBL14201113 | 0.79 | RIPK1 (0.32) | FDFT1RIPK1 | |
| SCHEMBL14201021 | 0.78 | RIPK1 (0.33) | FDFT1RIPK1P2RX7 | |
| SCHEMBL14201018 | 0.78 | PSEN1 (0.33) | ALDH1A1FDFT1RIPK1 | |
| SCHEMBL14229898 | 0.77 | TP53 (0.40) | ALDH1A1MLYCDTP53 | |
| SCHEMBL14200873 | 0.77 | RIPK1 (0.32) | FDFT1RIPK1 | |
| SCHEMBL14201042 | 0.77 | TSHR (0.31) | FDFT1POLBRIPK1 | |
| SCHEMBL14200854 | 0.75 | L3MBTL1 (0.34) | ALDH1A1POLBAPEX1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |