Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | FDFT1 | P37268 | 4/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201113 | 0.93 | RIPK1 (0.32) | RIPK1FDFT1 | |
| SCHEMBL14201021 | 0.88 | RIPK1 (0.33) | RIPK1FDFT1 | |
| SCHEMBL14229417 | 0.87 | TAS1R3 (0.31) | TSHR | |
| SCHEMBL14200872 | 0.86 | MLYCD (0.33) | MMP2 | |
| SCHEMBL14201018 | 0.85 | PSEN1 (0.33) | RIPK1FDFT1 | |
| SCHEMBL14200873 | 0.82 | RIPK1 (0.32) | RIPK1FDFT1 | |
| SCHEMBL14200471 | 0.80 | ALDH1A1 (0.41) | TSHRMMP2 | |
| SCHEMBL14200825 | 0.80 | POLB (0.33) | RIPK1POLB | |
| SCHEMBL14201040 | 0.80 | ALDH1A1 (0.36) | TSHRFDFT1 | |
| SCHEMBL14229078 | 0.79 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |