Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201196 | 0.93 | MLYCD (0.38) | MLYCDSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL14229566 | 0.88 | RIPK1 (0.45) | MLYCDSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL14200764 | 0.82 | ALDH1A1 (0.38) | MLYCDSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14201130 | 0.80 | MLYCD (0.40) | MLYCDSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL14201190 | 0.80 | MLYCD (0.44) | MLYCDRXRARXRBRXRG | |
| SCHEMBL14201185 | 0.80 | RIPK1 (0.33) | SMN1; SMN2CYP2C19RIPK1S1PR1 | |
| SCHEMBL14230251 | 0.80 | RIPK1 (0.43) | MLYCDRIPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL14229428 | 0.80 | TP53 (0.50) | MLYCDSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14201153 | 0.80 | RIPK1 (0.34) | SMN1; SMN2CYP2C19RIPK1 | |
| SCHEMBL14201195 | 0.78 | POLB (0.33) | RIPK1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |