Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 6/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178262 | 0.90 | GPR6 (0.35) | GPR6GRIN1GRIN2BPTGDR2GUCY1A1 | |
| SCHEMBL1178260 | 0.90 | GPR6 (0.35) | GPR6GRIN1GRIN2BPTGDR2GUCY1A1 | |
| SCHEMBL1179381 | 0.80 | EGLN2 (0.34) | GPR6GRIN1GRIN2BPTGDR2GUCY1A1 | |
| SCHEMBL1179379 | 0.80 | EGLN2 (0.34) | GPR6GRIN1GRIN2BPTGDR2GUCY1A1 | |
| SCHEMBL1420956 | 0.79 | SCARB1 (0.34) | GPR6PTGDR2SCARB1ADAM17PDE5A | |
| SCHEMBL13563272 | 0.79 | SCARB1 (0.48) | GPR6SCARB1 | |
| SCHEMBL13626291 | 0.77 | PPARG (0.33) | PTGDR2PPARGADAM17 | |
| SCHEMBL1178508 | 0.76 | ADORA2A (0.39) | GPR6PTGDR2ADORA2AADORA1CNR1 | |
| SCHEMBL1178506 | 0.76 | ADORA2A (0.39) | GPR6PTGDR2ADORA2AADORA1CNR1 | |
| SCHEMBL12579040 | 0.76 | SCARB1 (0.36) | PTGDR2GUCY1A1GUCY1B1KCNH2SCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297100-A1 | TETRAHYDROCYCLOPENTAÝB¨INDOLE ANDROGEN RECEPTOR MODULATORS | Eli Lilly & Company (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009140448-A1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2009-11-19 | — | — | WO | disclosed |