Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 6/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 2/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.34 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.34 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626290 | 0.85 | HTR6 (0.54) | SCARB1HTR6PTGS1PTGS2CA1 | |
| SCHEMBL1420956 | 0.80 | SCARB1 (0.34) | SCARB1HTR6HRH1PDE5A | |
| SCHEMBL1178469 | 0.77 | SCARB1 (0.33) | SCARB1HTR6HRH1RORCPDE5A | |
| SCHEMBL1178467 | 0.77 | SCARB1 (0.33) | SCARB1HTR6HRH1RORCPDE5A | |
| SCHEMBL13563272 | 0.75 | SCARB1 (0.48) | SCARB1HTR6HRH1PTGS1PTGS2 | |
| SCHEMBL14218042 | 0.74 | HRH1 (0.60) | SCARB1HTR6HRH1RORCCA1 | |
| SCHEMBL541977 | 0.73 | RORC (0.59) | SCARB1HTR6HRH1RORCCA1 | |
| SCHEMBL13478810 | 0.72 | HTR6 (0.60) | SCARB1HTR6HRH1RORCCA1 | |
| SCHEMBL4194079 | 0.69 | SCARB1 (0.67) | SCARB1HTR6HRH1RORCCA1 | |
| SCHEMBL14217953 | 0.68 | SCARB1 (0.49) | SCARB1HTR6HRH1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297100-B1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | LILLY CO ELI (US) | 2012-10-31 | — | — | EP | disclosed |