SCHEMBL140747

SCHEMBL140747

COCCOCCOc1cc(F)c(C#Cc2cc(F)c(C#N)c(F)c2)c(F)c1

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
APP P05067 13/20 0.36
SQOR Q9Y6N5 1/20 0.35
AR P10275 1/20 0.34
KDM4E B2RXH2 1/20 0.33
RECQL P46063 1/20 0.33
TRPV4 Q9HBA0 1/20 0.33
MGAT2 Q10469 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL142273 0.91 APP (0.34) APPSQORARKDM4ERECQL
SCHEMBL142121 0.87 RARB (0.44) APPKDM4E
SCHEMBL20546963 0.86 TRPV4 (0.42) SQORARKDM4ETRPV4MGAT2
SCHEMBL29225925 0.85 TRPV4 (0.37) KDM4ETRPV4MGAT2
SCHEMBL13049296 0.84 SQOR (0.39) SQORARKDM4ERECQLTRPV4
SCHEMBL141714 0.81 RARB (0.44) APPSQORARKDM4ERECQL
SCHEMBL30933448 0.81 MAPT (0.36) KDM4ETRPV4MGAT2
SCHEMBL30933449 0.81 MAPT (0.36) KDM4ETRPV4MGAT2
SCHEMBL14964488 0.80 RARB (0.42) APPKDM4EMGAT2
SCHEMBL14964489 0.79 KDM4E (0.42) APPKDM4EMGAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130341573-A1 PHOTOREFRACTIVE COMPOSITION COMPRISING ELECTROLYTES IN A PHOTOREFRACTIVE LAYER AND METHOD OF MAKING THEREOF NITTO DENKO CORPORATION (JP) 2013-12-26 US disclosed
US-20130341574-A1 PHOTOREFRACTIVE COMPOSITION AND DEVICE COMPRISING THE COMPOSITION NITTO DENKO CORPORATION (JP) 2013-12-26 US disclosed
WO-2013075050-A1 PHOTOREFRACTIVE DEVICE CONTAINING CARBON NANOTUBE-DOPED POLYMER LAYERS AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-05-23 WO disclosed
WO-2013075050-A1 PHOTOREFRACTIVE DEVICE CONTAINING CARBON NANOTUBE-DOPED POLYMER LAYERS AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-05-23 WO disclosed
US-8420235-B2 Emissive diaryl acetylenes NITTO DENKO CORPORATION (JP) 2013-04-16 US disclosed
US-8420235-B2 Emissive diaryl acetylenes NITTO DENKO CORPORATION (JP) 2013-04-16 US disclosed
WO-2012116071-A1 PHOTOREFRACTIVE COMPOSITION COMPRISING ELECTROLYTES IN A PHOTOREFRACTIVE LAYER AND METHOD OF MAKING THEREOF NITTO DENKO CORPORATION (JP) 2012-08-30 WO disclosed
WO-2012116105-A1 A PHOTOREFRACTIVE COMPOSITION AND DEVICE COMPRISING THE COMPOSITION NITTO DENKO CORPORATION (JP) 2012-08-30 WO disclosed
US-20120058418-A1 THREE-DIMENSIONAL HOLOGRAPHIC DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2012-03-08 US disclosed
US-20120058418-A1 THREE-DIMENSIONAL HOLOGRAPHIC DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2012-03-08 US disclosed
WO-2010141754-A1 EMISSIVE DIARYL ACETYLENES NITTO DENKO CORPORATION (JP) 2010-12-09 WO disclosed
US-20100308716-A1 EMISSIVE DIARYL ACETYLENES NITTO DENKO CORPORATION (JP) 2010-12-09 US disclosed
US-20100308716-A1 EMISSIVE DIARYL ACETYLENES NITTO DENKO CORPORATION (JP) 2010-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100308716-A1 EMISSIVE DIARYL ACETYLENES B3GNT2, GSTO1, NAT1 APP 2230/4885SQOR 148/4885AR 1031/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.