Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | SDHB | P21912 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423201 | 0.89 | KDM4E (0.45) | MAPTMEN1KMT2AKMOADORA2A | |
| SCHEMBL1085063 | 0.87 | KMO (0.46) | MAPTMEN1KMT2AKMOADORA2A | |
| SCHEMBL1420936 | 0.86 | KMO (0.53) | MAPTMEN1KMT2AKMOADORA2A | |
| SCHEMBL1085386 | 0.81 | ALDH1A1 (0.57) | MAPTMEN1KMT2AKMOALDH1A1 | |
| SCHEMBL1085513 | 0.79 | CYP3A4 (0.49) | MAPTMEN1KMT2AKDM4EHPGD | |
| SCHEMBL1085376 | 0.79 | XDH (0.56) | MAPTMEN1KMT2AKMOADORA2A | |
| SCHEMBL1085196 | 0.79 | KMO (0.50) | MAPTMEN1KMT2AKMOADORA2A | |
| SCHEMBL3873524 | 0.78 | KMO (0.52) | MAPTMEN1KMT2AKMOADORA2A | |
| SCHEMBL4427485 | 0.77 | SMN1; SMN2 (0.60) | MAPTMEN1KMT2AKMOALDH1A1 | |
| SCHEMBL1085229 | 0.76 | KDM4E (0.42) | MAPTMEN1KMT2AKMOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102066359-B | Novel heteroaryl carboxamide derivatives | HOFFMANN LA ROCHE | 2013-08-21 | — | — | CN | disclosed |
| US-8227613-B2 | Heteroaryl carboxamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-07-24 | — | — | US | disclosed |
| CN-102066359-A | Novel heteroaryl carboxamide derivatives | HOFFMANN LA ROCHE | 2011-05-18 | — | — | CN | disclosed |
| EP-2297137-A1 | NOVEL HETEROARYL CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-03-23 | — | — | EP | disclosed |
| US-20090318467-A1 | NOVEL HETEROARYL CARBOXAMIDE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-12-24 | — | — | US | disclosed |
| WO-2009153182-A1 | NOVEL HETEROARYL CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318467-A1 | NOVEL HETEROARYL CARBOXAMIDE DERIVATIVES | CCR3, CCR2, CCR1 | MAPT 4476/4885MEN1 3975/4885KMT2A 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.