Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.61 |
| ▸ | MTOR | P42345 | 11/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.50 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214546 | 0.88 | PIK3CA (0.48) | PIK3CAMTORKDRPIK3CDPIK3CB | |
| SCHEMBL14214544 | 0.87 | PIK3CA (0.46) | PIK3CAMTORKDRAURKAEGFR | |
| SCHEMBL14214545 | 0.87 | AURKA (0.47) | PIK3CAMTORKDRPIK3CDPIK3CB | |
| SCHEMBL14214540 | 0.81 | GSK3B (0.43) | PIK3CAMTORKDRAURKAEGFR | |
| SCHEMBL14214630 | 0.81 | LCK (0.51) | KDRAURKAPTK6PLK1PTK2 | |
| SCHEMBL14214629 | 0.81 | GABRP (0.46) | KDRAURKAHSP90AA1LCKMAPK14 | |
| SCHEMBL14214683 | 0.81 | SYK (0.42) | PIK3CAMTORKDRBRAFRAF1 | |
| SCHEMBL14214536 | 0.81 | MAPK1 (0.50) | PIK3CAMTORKDREGFRPTK6 | |
| SCHEMBL14214543 | 0.78 | CCNT1 (0.46) | PIK3CDPIK3CGAURKAAURKB | |
| SCHEMBL14214622 | 0.76 | LCK (0.43) | PIK3CAMTORKDRPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |