Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 7/20 | 0.46 |
| ▸ | CDK1 | P06493 | 7/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.46 |
| ▸ | CDK9 | P50750 | 7/20 | 0.46 |
| ▸ | CDK7 | P50613 | 3/20 | 0.46 |
| ▸ | CCNH | P51946 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214540 | 0.87 | GSK3B (0.43) | AURKAAURKBGSK3B | |
| SCHEMBL14214546 | 0.85 | PIK3CA (0.48) | PIK3CDAURKAPIK3CGAURKBGSK3B | |
| SCHEMBL14214544 | 0.80 | PIK3CA (0.46) | AURKA | |
| SCHEMBL14214629 | 0.80 | GABRP (0.46) | AURKAGSK3B | |
| SCHEMBL14214626 | 0.80 | CDK1 (0.47) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL14214630 | 0.78 | LCK (0.51) | CDK2AURKAGSK3B | |
| SCHEMBL14214608 | 0.78 | GSK3B (0.41) | AURKAGSK3B | |
| SCHEMBL14214545 | 0.78 | AURKA (0.47) | PIK3CDAURKAPIK3CG | |
| SCHEMBL14214537 | 0.78 | PIK3CA (0.61) | PIK3CDAURKAPIK3CGAURKB | |
| SCHEMBL14214536 | 0.78 | MAPK1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |