Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | MTOR | P42345 | 3/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.45 |
| ▸ | GABRE | P78334 | 2/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214544 | 0.87 | PIK3CA (0.46) | AURKAPIK3CAMTORSCN9ALCK | |
| SCHEMBL14214537 | 0.87 | PIK3CA (0.61) | AURKAPIK3CAMTORLCKKDR | |
| SCHEMBL14214630 | 0.83 | LCK (0.51) | AURKAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14214540 | 0.81 | GSK3B (0.43) | AURKAPIK3CAMTORGABRPGABRD | |
| SCHEMBL14214546 | 0.81 | PIK3CA (0.48) | AURKAPIK3CAMTORGABRPGABRD | |
| SCHEMBL14214629 | 0.81 | GABRP (0.46) | AURKAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14214683 | 0.81 | SYK (0.42) | PIK3CAMTORLCKKDRMAPK14 | |
| SCHEMBL14214536 | 0.81 | MAPK1 (0.50) | PIK3CAMTORGABRPGABRDGABRA1 | |
| SCHEMBL14214622 | 0.78 | LCK (0.43) | AURKAPIK3CAMTORGABRPGABRD | |
| SCHEMBL14214543 | 0.78 | CCNT1 (0.46) | AURKAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |