Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214540 | 0.89 | GSK3B (0.43) | PIK3CAMTORGSK3BAURKAKDR | |
| SCHEMBL14214537 | 0.88 | PIK3CA (0.61) | PIK3CAMTORHSP90AA1AURKAKDR | |
| SCHEMBL14214543 | 0.85 | CCNT1 (0.46) | GSK3BAURKAAURKBPIK3CDPIK3CG | |
| SCHEMBL14214629 | 0.83 | GABRP (0.46) | GSK3BHSP90AA1AURKAKDRLCK | |
| SCHEMBL14214630 | 0.82 | LCK (0.51) | GSK3BAURKAKDRLCKMAPK14 | |
| SCHEMBL14214608 | 0.81 | GSK3B (0.41) | PIK3CAMTORGSK3BAURKAKDR | |
| SCHEMBL14214545 | 0.81 | AURKA (0.47) | PIK3CAMTORAURKAKDRLCK | |
| SCHEMBL14214544 | 0.81 | PIK3CA (0.46) | PIK3CAMTORAURKAKDRLCK | |
| SCHEMBL14214536 | 0.81 | MAPK1 (0.50) | PIK3CAMTORHSP90AA1KDRGABRP | |
| SCHEMBL14214622 | 0.81 | LCK (0.43) | PIK3CAMTORGSK3BAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |