Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 5/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380902 | 0.89 | MKNK1 (0.55) | MKNK1MKNK2AURKAROCK1PIK3CG | |
| SCHEMBL14214728 | 0.84 | MKNK1 (0.53) | MKNK1MKNK2MAPK8MAPK10AURKA | |
| SCHEMBL14380908 | 0.82 | MAPK8 (0.47) | MKNK1MKNK2MAPK8MAPK10AURKB | |
| SCHEMBL14380900 | 0.81 | MKNK1 (1.00) | MKNK1MKNK2MAPK8MAPK10CDK2 | |
| SCHEMBL14380903 | 0.80 | AURKA (0.52) | MKNK1MKNK2MAPK8MAPK10AURKA | |
| SCHEMBL14214732 | 0.75 | SCN9A (0.59) | ROCK1PIK3CG | |
| SCHEMBL14380858 | 0.74 | KDR (0.56) | CDK2LCKJAK2FLT3PIK3CG | |
| SCHEMBL14380906 | 0.74 | MKNK1 (0.40) | MKNK1MKNK2MAPK8MAPK10CDK2 | |
| SCHEMBL3244139 | 0.72 | PIK3CA (0.55) | AURKALCKJAK2FLT3PIK3CG | |
| SCHEMBL14380899 | 0.71 | MKNK1 (0.80) | MKNK1MKNK2CDK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |