Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20390649 | 0.71 | ALDH1A1 (0.44) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL13984050 | 0.71 | — | — | |
| SCHEMBL10719025 | 0.68 | ALDH1A1 (0.61) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL24107845 | 0.64 | MAPT (0.41) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10696282 | 0.63 | SIGMAR1 (0.42) | ALDH1A1LMNAHTT | |
| SCHEMBL13076339 | 0.63 | ALDH1A1 (0.43) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1771825 | 0.61 | ALDH1A1 (0.79) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10699144 | 0.60 | CHRM2 (0.41) | — | |
| SCHEMBL13189792 | 0.59 | MPL (0.41) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL23610361 | 0.59 | ALDH1A1 (0.83) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057862-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-15 | — | — | WO | disclosed |