SCHEMBL14215824

SCHEMBL14215824

O=C(c1ccccc1)c1ccc(O)cc1Nc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.60
MEN1 O00255 2/20 0.60
USP2 O75604 1/20 0.60
GAA P10253 1/20 0.60
KEAP1 Q14145 1/20 0.60
NFE2L2 Q16236 1/20 0.60
MAPK13 O15264 4/20 0.51
MAPK12 P53778 4/20 0.51
MAPK11 Q15759 4/20 0.51
MAPK14 Q16539 4/20 0.51
MAPT P10636 2/20 0.49
GFER P55789 2/20 0.49
NGLY1 Q96IV0 1/20 0.49
AKR1C3 P42330 2/20 0.47
AKR1C2 P52895 2/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
PSMB5 P28074 1/20 0.46
CDC25B P30305 1/20 0.46
ALDH1A1 P00352 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14189065 0.83 NPSR1 (0.56) KMT2AMEN1GAAMAPK13MAPK12
SCHEMBL10652552 0.82 MAPK13 (0.55) KMT2AMEN1USP2GAAKEAP1
SCHEMBL5357396 0.81 FABP4 (0.65) KMT2AMEN1MAPK13MAPK12MAPK11
SCHEMBL14215835 0.78 MAPT (0.46) KMT2AMEN1USP2GAAKEAP1
SCHEMBL7875193 0.77 MAPK13 (0.70) KMT2AMEN1USP2GAAKEAP1
SCHEMBL28021862 0.77 MEN1 (0.75) KMT2AMEN1USP2GAAKEAP1
SCHEMBL27487134 0.76 KMT2A (0.68) KMT2AMEN1USP2GAAKEAP1
2,4-Dihydroxybenzophenone SCHEMBL29351647 0.75 MEN1 (1.00) KMT2AMEN1USP2GAAKEAP1
2,4-Dihydroxybenzophenone SCHEMBL30201813 0.75 MEN1 (1.00) KMT2AMEN1USP2GAAKEAP1
2,4-Dihydroxybenzophenone SCHEMBL1699129 0.75 MEN1 (1.00) KMT2AMEN1USP2GAAKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7378154-B2 Radiation transparent glass, polycarbonate, polyethylene terephthalate, acrylic, methyl cellulose or polycycloolefin substrate, a fluoropolymer layer containing and a rare earth metal compound, and a low refractive index layer; fluorescence; light amplification; improved efficiency; light emitting diodes DAIKIN INDUSTRIES, LTD. (JP) 2008-05-27 US disclosed