Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 8/20 | 0.40 |
| ▸ | HTR1A | P08908 | 9/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985067 | 0.84 | ADRA1D (0.38) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL14188913 | 0.83 | HTR1A (0.38) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL4982940 | 0.82 | ADRA1D (0.36) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL4983809 | 0.81 | HTR1A (0.36) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL4977214 | 0.81 | TLR2 (0.43) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL4983055 | 0.79 | ADRA1D (0.35) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL4983803 | 0.79 | TMEM97 (0.40) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL14188911 | 0.79 | HTR1A (0.51) | ADRA1DHTR1AADRA1AADRA1B | |
| SCHEMBL4982169 | 0.78 | ADRA1D (0.41) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 | |
| SCHEMBL7510227 | 0.78 | HTR1A (0.46) | ADRA1DHTR1AADRA1AADRA1BHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | ADRA1D 18/4885HTR1A 4/4885ADRA1A 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.