Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510228 | 1.00 | HTR1A (0.46) | HTR1AADRA1AADRA1BADRA1DHCRTR1 | |
| SCHEMBL10713434 | 0.83 | ALDH1A1 (0.52) | HTR1AADRA1ASIGMAR1TMEM97 | |
| SCHEMBL14188914 | 0.83 | HTR2C (0.42) | HTR1AADRA1AADRA1BADRA1DSIGMAR1 | |
| SCHEMBL11873710 | 0.81 | TMEM97 (0.42) | HCRTR1HCRTR2CYP2D6SIGMAR1TMEM97 | |
| SCHEMBL4982940 | 0.81 | ADRA1D (0.36) | HTR1AADRA1AADRA1BADRA1DHCRTR1 | |
| SCHEMBL4983803 | 0.81 | TMEM97 (0.40) | HTR1AADRA1AADRA1BADRA1DHCRTR1 | |
| SCHEMBL4981417 | 0.81 | PYCR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL14403019 | 0.81 | CA2 (0.34) | HTR1AADRA1AADRA1BADRA1DHCRTR1 | |
| SCHEMBL4979407 | 0.81 | MAPT (0.44) | — | |
| SCHEMBL14188913 | 0.80 | HTR1A (0.38) | HTR1AADRA1AADRA1BADRA1DHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946561-B1 | TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| EP-0634408-B1 | DEPSIPEPTIDE DERIVATIVE, PRODUCTION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-6297232-B1 | TREATMENT OF PLATELET AGGREGATION DISORDERS. | ASTRAZENECA AB (SE) | 2001-10-02 | — | — | US | disclosed |
| CN-1039331-C | Depsispeptide derivative, preparation and application of same | FUJISAMA PHARMACEUTICAL CO LTD (JP) | 1998-07-29 | — | — | CN | disclosed |
| US-5514773-A | PARASITICIDES, ANTHELMINTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-07 | — | — | US | disclosed |
| EP-0634408-A1 | DEPSIPEPTIDE DERIVATIVE, PRODUCTION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-01-18 | — | — | EP | disclosed |
| CN-1080932-A | Depsipeptide derivative and manufacture method thereof and purposes | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-01-19 | — | — | CN | disclosed |