Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994446 | 0.81 | PKM (0.39) | HTR6KLK7DRD2DRD3TSHR | |
| SCHEMBL3621300 | 0.66 | HTT (0.49) | HTR6PKMMEN1KMT2AMAPT | |
| SCHEMBL4418508 | 0.66 | ALDH1A1 (0.39) | KLK7PKMMEN1KMT2AMAPT | |
| SCHEMBL5698306 | 0.65 | HTR6 (0.67) | HTR6DRD2 | |
| SCHEMBL1998486 | 0.65 | HTR6 (0.40) | HTR6KLK7DRD2DRD3TSHR | |
| SCHEMBL13504571 | 0.64 | HTT (0.44) | HTR6DRD2DRD3PKMMAPT | |
| SCHEMBL3620463 | 0.63 | HTT (0.46) | HTR6DRD2TSHRPKMMEN1 | |
| SCHEMBL6502257 | 0.63 | HTR6 (0.50) | HTR6KLK7DRD2DRD3PKM | |
| SCHEMBL1999301 | 0.63 | HTR6 (0.54) | HTR6DRD2DRD3 | |
| SCHEMBL1995653 | 0.63 | HTR6 (0.54) | HTR6DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054288-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (PUBL) (SE) | 2008-05-08 | — | — | WO | disclosed |