Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14347814 | 0.88 | LMNA (0.55) | LMNAMAOBMAOATAAR1CNR1 | |
| SCHEMBL5737015 | 0.81 | TAAR1 (0.39) | LMNAMAOBMAOATAAR1L3MBTL1 | |
| SCHEMBL8351707 | 0.81 | LMNA (0.52) | LMNASLC6A3SLC6A4DPP4 | |
| SCHEMBL8355831 | 0.81 | LMNA (0.52) | LMNAMAOBMAOATAAR1CYP1A2 | |
| SCHEMBL8352672 | 0.79 | MAOA (0.61) | MAOBMAOATAAR1SLC6A3SLC6A4 | |
| SCHEMBL5737414 | 0.77 | MAOA (0.36) | MAOBMAOATAAR1SLC6A3SLC6A4 | |
| SCHEMBL2441363 | 0.75 | L3MBTL1 (0.43) | LMNACNR1CNR2OPRM1L3MBTL1 | |
| SCHEMBL14347818 | 0.73 | OPRM1 (0.45) | LMNAOPRM1L3MBTL1SLC6A3SLC6A4 | |
| SCHEMBL13799399 | 0.73 | MAOA (0.59) | MAOBMAOATAAR1OPRM1SLC6A3 | |
| SCHEMBL8352416 | 0.73 | SLC6A4 (0.39) | LMNAMAOBMAOAOPRM1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057575-A2 | NOVEL ARYLBICYCLO[3.1.0]HEXYLAMINES AND METHODS AND COMPOSITIONS FOR THEIR PREPARATION AND USE | DOV PHARMACEUTICAL, INC. (US) | 2008-05-15 | — | — | WO | disclosed |