Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216987 | 0.85 | HTR2A (0.44) | HTR2AHRH1ALDH1A1UTS2RLMNA | |
| SCHEMBL12550527 | 0.78 | ALDH1A1 (0.48) | KDM4EALDH1A1USP2FASNPTGS2 | |
| SCHEMBL14216819 | 0.77 | MTNR1A (0.53) | CASRALDH1A1MTNR1AMTNR1B | |
| SCHEMBL25395406 | 0.76 | ALDH1A1 (0.48) | KDM4EALDH1A1CYP3A4TSHRCYP2C19 | |
| SCHEMBL14217383 | 0.76 | HTR2A (0.53) | HTR2AHRH1CASRCCR5KDM4E | |
| SCHEMBL9053055 | 0.75 | HTR2A (0.60) | HTR2AHRH1KDM4EALDH1A1USP2 | |
| SCHEMBL14217373 | 0.74 | SIGMAR1 (0.48) | HTR2AHRH1KDM4EALDH1A1UTS2R | |
| SCHEMBL14216839 | 0.74 | HTR2A (0.44) | HTR2AHRH1CCR5KDM4EALDH1A1 | |
| SCHEMBL3905618 | 0.73 | HRH1 (0.58) | HTR2AHRH1KDM4EALDH1A1MTNR1A | |
| SCHEMBL1730118 | 0.70 | ALDH1A1 (0.48) | KDM4EALDH1A1USP2FASNPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125424-A1 | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor | GALAPAGOS SAS (FR) | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125424-A1 | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor | UTS2R, CASR, GPR17 | HTR2A 2787/4885HRH1 163/4885CASR 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.