Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 7/20 | 0.33 |
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25942285 | 0.81 | CYP11B1 (0.36) | PDE10AEGFRCRHR1RAB9ANPC1 | |
| SCHEMBL14217528 | 0.72 | ROCK1 (0.38) | ACVR2ATGFBR2EGFRRAB9ANPC1 | |
| SCHEMBL1683406 | 0.69 | HTR6 (0.46) | RAB9AALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL9959514 | 0.69 | TP53 (0.44) | ALDH1A1CYP1A2CYP3A4CYP2C9KDM4E | |
| SCHEMBL1683455 | 0.69 | KDM4E (0.44) | ALDH1A1HPGDCYP3A4SMN1; SMN2KDM4E | |
| SCHEMBL14819965 | 0.68 | APP (0.39) | ACVR2ATGFBR2EGFRRAB9ANPC1 | |
| SCHEMBL1683456 | 0.68 | KEAP1 (0.39) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL8133385 | 0.67 | APP (0.41) | EGFRRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL25941242 | 0.66 | CHRNA7 (0.36) | PDE10ARAB9ANPC1KDM4EMEN1 | |
| SCHEMBL15041953 | 0.64 | ALDH1A1 (0.55) | EGFRRAB9ANPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371765-B2 | Quinoline derivatives having VEGF inhibiting activity | ASTRAZENECA AB (SE) | 2008-05-13 | — | — | US | disclosed |