Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTC4S | Q16873 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.35 |
| ▸ | QPCT | Q16769 | 4/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265374 | 0.84 | CSF1R (0.38) | LTC4SGPBAR1QPCTPPARDCSF1R | |
| SCHEMBL265373 | 0.84 | CSF1R (0.38) | LTC4SGPBAR1QPCTPPARDCSF1R | |
| SCHEMBL264165 | 0.78 | GPBAR1 (0.37) | GPBAR1PPARDCSF1R | |
| SCHEMBL264166 | 0.78 | GPBAR1 (0.37) | GPBAR1PPARDCSF1R | |
| SCHEMBL1422138 | 0.78 | ALDH1A1 (0.33) | GPBAR1PPARDMEN1CYP3A4CYP2D6 | |
| SCHEMBL1422511 | 0.76 | TRPM8 (0.35) | PPARDMEN1KMT2A | |
| SCHEMBL1422515 | 0.76 | TRPM8 (0.34) | PPARDMEN1KMT2A | |
| SCHEMBL1422609 | 0.76 | GPBAR1 (0.34) | LTC4SGPBAR1PPARDPOLQMEN1 | |
| SCHEMBL1422607 | 0.76 | GPBAR1 (0.34) | LTC4SGPBAR1PPARDPOLQMEN1 | |
| SCHEMBL265595 | 0.75 | P2RX7 (0.39) | PPARDTRPA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297102-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-03-23 | — | — | EP | disclosed |