Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | GPR183 | P32249 | 10/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.48 |
| ▸ | ITGAL | P20701 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13636500 | 0.86 | GPR183 (0.52) | TDP1GPR183ALDH1A1MEN1KMT2A | |
| SCHEMBL4382910 | 0.86 | GPR183 (0.52) | TDP1GPR183ALDH1A1MEN1KMT2A | |
| SCHEMBL14190937 | 0.80 | ALDH1A1 (0.47) | GPR183ALDH1A1ITGB2ICAM1ITGAL | |
| SCHEMBL4383997 | 0.80 | ALDH1A1 (0.47) | GPR183ALDH1A1ITGB2ICAM1ITGAL | |
| SCHEMBL4382905 | 0.79 | ALDH1A1 (0.46) | GPR183ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14190922 | 0.79 | ALDH1A1 (0.46) | GPR183ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14190914 | 0.79 | LMNA (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4384525 | 0.79 | LMNA (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2485549 | 0.78 | GPR183 (0.67) | TDP1GPR183ALDH1A1MEN1KMT2A | |
| SCHEMBL2832628 | 0.77 | ITGAL (0.45) | GPR183ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | TDP1 3908/4885GPR183 264/4885ALDH1A1 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.