Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 4/20 | 0.44 |
| ▸ | ITGAL | P20701 | 5/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190922 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNATP53GPR183ITGAL | |
| SCHEMBL4383997 | 0.99 | ALDH1A1 (0.47) | ALDH1A1LMNATP53GPR183ITGAL | |
| SCHEMBL14190937 | 0.99 | ALDH1A1 (0.47) | ALDH1A1LMNATP53GPR183ITGAL | |
| SCHEMBL2832628 | 0.90 | ITGAL (0.45) | ALDH1A1LMNATP53GPR183ITGAL | |
| SCHEMBL14218005 | 0.79 | TDP1 (0.60) | ALDH1A1GPR183ITGALITGB2ICAM1 | |
| SCHEMBL4382910 | 0.77 | GPR183 (0.52) | ALDH1A1LMNATP53GPR183ITGAL | |
| SCHEMBL13636500 | 0.77 | GPR183 (0.52) | ALDH1A1LMNATP53GPR183ITGAL | |
| SCHEMBL14190914 | 0.76 | LMNA (0.49) | ALDH1A1LMNATP53MEN1KMT2A | |
| SCHEMBL4384525 | 0.76 | LMNA (0.49) | ALDH1A1LMNATP53MEN1KMT2A | |
| SCHEMBL29259756 | 0.75 | GAA (0.64) | ALDH1A1LMNATP53GPR183KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |