Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190914 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL14218005 | 0.79 | TDP1 (0.60) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL14190937 | 0.77 | ALDH1A1 (0.47) | LMNAALDH1A1TP53 | |
| SCHEMBL13636500 | 0.77 | GPR183 (0.52) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL4383997 | 0.77 | ALDH1A1 (0.47) | LMNAALDH1A1TP53 | |
| SCHEMBL4382910 | 0.77 | GPR183 (0.52) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL4382905 | 0.76 | ALDH1A1 (0.46) | LMNASMN1; SMN2ALDH1A1TP53MEN1 | |
| SCHEMBL14190922 | 0.76 | ALDH1A1 (0.46) | LMNASMN1; SMN2ALDH1A1TP53MEN1 | |
| SCHEMBL27557310 | 0.76 | ITGAL (0.65) | LMNASMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL2832628 | 0.75 | ITGAL (0.45) | LMNASMN1; SMN2ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |