Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10173395 | 0.86 | L3MBTL1 (0.40) | CHRNB2CHRNA4KMT2ATHRBSMN1; SMN2 | |
| SCHEMBL8404353 | 0.77 | CHRNB2 (0.55) | CHRNB2CHRNA4KMT2ALMNACHRM2 | |
| SCHEMBL13182376 | 0.72 | — | — | |
| SCHEMBL12283650 | 0.72 | — | — | |
| SCHEMBL25043991 | 0.72 | CHRNB2 (0.63) | CHRNB2CHRNA4CHIALMNACHRM2 | |
| SCHEMBL6127902 | 0.68 | ALDH1A1 (0.43) | KMT2ALMNAHTT | |
| SCHEMBL13947189 | 0.68 | CHRNB2 (0.37) | CHRNB2CHRNA4LMNACHRM2CHRM4 | |
| SCHEMBL27242696 | 0.67 | CHRNB2 (0.41) | CHRNB2CHRNA4KMT2ACHIALMNA | |
| SCHEMBL4572644 | 0.67 | CHRNB2 (0.47) | CHRNB2CHRNA4KMT2ALMNASMN1; SMN2 | |
| SCHEMBL4572657 | 0.64 | CHRNB2 (0.38) | CHRNB2CHRNA4KMT2ALMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368452-B2 | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2008-05-06 | — | — | US | disclosed |