Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20448655 | 0.86 | RIPK1 (0.37) | RIPK1HSD11B1LMNAMAOA | |
| SCHEMBL25280393 | 0.81 | CHRNB2 (0.42) | RIPK1HPGD | |
| SCHEMBL1920132 | 0.73 | DPP4 (0.40) | RIPK1LMNADPP4DPP8DPP9 | |
| SCHEMBL5002190 | 0.73 | DPP4 (0.40) | RIPK1LMNADPP4DPP8DPP9 | |
| SCHEMBL2430899 | 0.73 | DPP4 (0.40) | RIPK1LMNADPP4DPP8DPP9 | |
| SCHEMBL14480015 | 0.73 | DPP4 (0.40) | RIPK1LMNADPP4DPP8DPP9 | |
| SCHEMBL3514728 | 0.72 | RAB9A (0.37) | RIPK1LMNAGFERDPP4GAA | |
| SCHEMBL3514730 | 0.72 | RAB9A (0.37) | RIPK1LMNAGFERDPP4GAA | |
| SCHEMBL22443043 | 0.71 | KDM5A (0.36) | RIPK1LMNADPP4 | |
| SCHEMBL12478830 | 0.71 | PPID (0.48) | RIPK1HSD11B1PPIDGFERSLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336120-A1 | Combinations containing amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors | Istituto di ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2011-06-22 | — | — | EP | disclosed |
| EP-2109608-B1 | AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2011-03-23 | — | — | EP | disclosed |