Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 9/20 | 0.42 |
| ▸ | CLCN2 | P51788 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219570 | 0.90 | DHODH (0.48) | LMNAGAADHODHCLCN2MEN1 | |
| SCHEMBL14219689 | 0.88 | DHODH (0.39) | LMNAGAADHODHCLCN2SORT1 | |
| SCHEMBL14222457 | 0.88 | DHODH (0.41) | LMNAGAADHODHCLCN2MEN1 | |
| SCHEMBL14219676 | 0.88 | MAP2K1 (0.40) | LMNAGAADHODHCLCN2SORT1 | |
| SCHEMBL14222456 | 0.88 | DHODH (0.39) | LMNAGAADHODHCLCN2SORT1 | |
| SCHEMBL14219819 | 0.87 | DHODH (0.46) | LMNAGAADHODHMEN1KMT2A | |
| SCHEMBL14219684 | 0.85 | LMNA (0.42) | LMNAGAADHODHCLCN2MEN1 | |
| SCHEMBL14219656 | 0.82 | PTGS2 (0.41) | LMNAGAADHODHMEN1KMT2A | |
| SCHEMBL14219621 | 0.81 | MAP2K1 (0.48) | LMNAGAADHODHMEN1KMT2A | |
| SCHEMBL14223199 | 0.81 | DHODH (0.51) | DHODHCLCN2MEN1KMT2ASORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |