Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | PTGES | O14684 | 2/20 | 0.48 |
| ▸ | TYR | P14679 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15107045 | 0.99 | TOP2A (0.52) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL15371640 | 0.93 | MMP9 (0.51) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL15371647 | 0.93 | MMP9 (0.51) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL13125809 | 0.89 | TOP2A (0.59) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL14219883 | 0.79 | TUBB4A (0.46) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL16310168 | 0.79 | APP (0.46) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL12261878 | 0.77 | TOP2A (0.69) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL12336320 | 0.77 | TOP2A (0.69) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL13827364 | 0.76 | MAPT (0.49) | TOP2AALOX5APPMAPTBACE1 | |
| SCHEMBL22493386 | 0.75 | TOP2A (0.89) | TOP2AALOX5APPMAPTBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447023-B2 | Curcumin and tetrahydrocurcumin derivatives | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2016-09-20 | — | — | US | disclosed |
| EP-2813145-A1 | Novel curcumin and tetrahydrocurcumin derivatives | Research Foundation Of The City University Of New York (US) | 2014-12-17 | — | — | EP | disclosed |
| US-20130296527-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2013-11-07 | — | — | US | disclosed |
| US-8487139-B2 | Curcumin and tetrahydrocurcumin derivatives | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2013-07-16 | — | — | US | disclosed |
| US-8487139-B2 | Curcumin and tetrahydrocurcumin derivatives | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2013-07-16 | — | — | US | disclosed |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2008045534-A2 | NOVEL CURCUMIN AND TETRAHYDROCURCUMIN DERIVATIVES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | BHMT2, HMOX1, DEPTOR | TOP2A 1586/4885ALOX5 1224/4885APP 694/4885 |
| US-20130296527-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | BHMT2, HMOX1, DEPTOR | TOP2A 1586/4885ALOX5 1224/4885APP 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.