Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185644 | 0.75 | CTSA (0.42) | ALDH1A1LMNA | |
| SCHEMBL185423 | 0.74 | CTSA (0.44) | ALDH1A1HPGD | |
| SCHEMBL14577222 | 0.72 | GPR88 (0.46) | ALOX15ACHEALDH1A1LMNAKMT2A | |
| SCHEMBL11947652 | 0.69 | REN (0.50) | ACHEALDH1A1LMNAHTT | |
| SCHEMBL5089567 | 0.68 | CTSA (0.54) | — | |
| SCHEMBL25278123 | 0.68 | NCEH1 (0.58) | ALDH1A1TSHRHTT | |
| SCHEMBL14696749 | 0.68 | TSHR (0.46) | ALOX15ALDH1A1LMNATSHRHTT | |
| SCHEMBL13296433 | 0.67 | ACHE (0.66) | ALOX15ACHEALDH1A1LMNA | |
| SCHEMBL17663562 | 0.67 | ACHE (0.66) | ALOX15ACHE | |
| SCHEMBL1667805 | 0.67 | HTT (0.72) | ACHEALDH1A1LMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423382-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2008-04-16 | — | — | EP | disclosed |