Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14220860 | 0.89 | IDO1 (0.46) | IDO1SMN1; SMN2PKMKMT2APOLB | |
| SCHEMBL14221370 | 0.88 | ALDH1A1 (0.56) | IDO1SMN1; SMN2KMT2ACYP3A4CYP2C19 | |
| SCHEMBL14282207 | 0.86 | NPBWR1 (0.48) | IDO1SMN1; SMN2KMT2APOLBCYP3A4 | |
| SCHEMBL14282209 | 0.86 | NOTUM (0.54) | IDO1SMN1; SMN2KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL14282208 | 0.81 | RAB9A (0.53) | SMN1; SMN2KMT2ACYP3A4CYP2C19PPARG | |
| SCHEMBL14282213 | 0.81 | CYP17A1 (0.56) | SMN1; SMN2PKMKMT2APOLBCYP3A4 | |
| SCHEMBL14282212 | 0.80 | GAA (0.48) | IDO1SMN1; SMN2KMT2ACYP3A4CYP2C19 | |
| SCHEMBL14282211 | 0.78 | NPBWR1 (0.46) | SMN1; SMN2KMT2ACYP3A4NPSR1ALDH1A1 | |
| SCHEMBL14282214 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL710352 | 0.76 | IDO1 (1.00) | IDO1KMT2ACYP3A4NCOA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497269-B1 | SUBSTITUTED 2-PHENYL-3(2H)-PYRIDAZINONES | BAYER HEALTHCARE AG (DE) | 2008-04-23 | — | — | EP | disclosed |
| US-7320977-B2 | Fibrotic disorders; disorders characterized by harmful buildup of collagen and/or by excessive lysyl oxidase enzymatic activity | BAYER HEALTHCARE AG (DE) | 2008-01-22 | — | — | US | disclosed |
| US-7320977-B2 | Fibrotic disorders; disorders characterized by harmful buildup of collagen and/or by excessive lysyl oxidase enzymatic activity | BAYER HEALTHCARE AG (DE) | 2008-01-22 | — | — | US | disclosed |